Amyloid goiter with hypothyroidism

Whereas the microscopic infiltration of the thyroid by amyloid is a common phenomenon, significant enlargement of the gland due to the deposition of amyloid is infrequent. Amyloid goiter usually occurs as one of the unusual manifestations of systemic amyloidosis. The rapid growth associated with local pressure symptoms often suggests malignancy. In spite of the extensive infiltration of the gland by amyloid, thyroid function usually remains euthyroid. We have recently observed an unusual case of multicentric giant lymph node hyperplasia in a patient who developed amyloid goiter with hypothyroidism. The amyloid material was of AA type.