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Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
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Herpesvirus Entry into Host Cells Mediated by Endosomal Low pH
1Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164, USA.
Traffic (Copenhagen, Denmark)
|April 30, 2016
Summary
Herpes simplex virus 1 (HSV-1) uses low pH endocytosis for entry into epithelial cells. Mildly acidic conditions alter its glycoprotein B, impacting infectivity.
Area of Science:
- Virology
- Cell Biology
- Pathogenesis
Background:
- Herpesviruses infect diverse cell types, utilizing various entry pathways.
- Understanding viral entry mechanisms is crucial for controlling herpesviral infections.
Purpose of the Study:
- To review the role of endosomal acidity in herpesvirus entry.
- To focus on herpes simplex virus 1 (HSV-1) entry into epithelial cells.
Main Methods:
- Review of existing literature on herpesvirus entry.
- Analysis of the impact of low pH on viral glycoproteins and infectivity.
Main Results:
- Epithelial cells facilitate HSV-1 entry via low pH endocytosis.
- Mildly acidic pH induces conformational changes in HSV-1 glycoprotein B (gB).
- Low pH inactivates virions in vitro by premature activation of entry machinery.
Conclusions:
- Endosomal acidity is a significant factor in herpesvirus entry.
- The precise mechanisms by which herpesviruses achieve both low pH and pH-independent entry remain unclear.
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