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Related Experiment Video

Updated: Mar 22, 2026

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

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Published on: October 10, 2025

Polypeptide-Based Gold Nanoshells for Photothermal Therapy.

Kristine M Mayle¹, Kathryn R Dern¹, Vincent K Wong¹

¹1 Department of Bioengineering, University of California, Los Angeles, CA, USA.

SLAS Technology

|April 30, 2016

Summary

This summary is machine-generated.

Researchers developed novel gold nanoshells using polypeptide cores for targeted cancer therapy. These nanoparticles generate heat under near-infrared light, enabling localized cancer cell destruction with low toxicity.

Keywords:

cancer gold nanoshells nanoparticles photothermal therapies polypeptide vesicles

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Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods

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Last Updated: Mar 22, 2026

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Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods

Published on: May 2, 2016

Area of Science:

Biomaterials Science
Nanotechnology
Cancer Therapy

Background:

Targeted cancer therapy using nanoparticles offers noninvasive treatment potential.
Photothermal therapy relies on materials that generate heat upon light exposure to destroy cancer cells.

Purpose of the Study:

To design and create novel gold nanoshells utilizing self-assembled block copolypeptide vesicles as cores.
To evaluate the photothermal properties, toxicity, and efficacy of these novel gold nanoshells for cancer treatment.

Main Methods:

Synthesis of poly(L-lysine)-block-poly(L-leucine) (K60L20) block copolypeptide vesicles.
Coating the polypeptide vesicles with a thin layer of gold to form gold nanoshells.
Characterization of light absorption, heat generation, and in vitro cytotoxicity upon near-infrared laser irradiation.
Development and experimental validation of a mathematical heat transfer model.

Main Results:

The K60L20 gold nanoshells exhibited enhanced near-infrared light absorption due to surface plasmon resonance.
These nanoshells demonstrated low toxicity without laser exposure but induced localized cytotoxicity upon irradiation.
A validated mathematical model was established to predict temperature changes and optimize nanoshell design for enhanced heat generation.

Conclusions:

Block copolypeptide vesicles serve as a viable core material for novel gold nanoshells.
These polypeptide-based gold nanoshells show promise for targeted, noninvasive photothermal cancer therapy.
The developed mathematical model aids in optimizing nanoparticle design for improved therapeutic outcomes.