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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
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Vitamin D Pathway Gene Polymorphisms and Keratinocyte Cancers: A Nested Case-Control Study and Meta-Analysis
Lena A VON Schuckmann1, Matthew H Law2, Grant W Montgomery2
1The University of Queensland, School of Public Health, Herston, Australia QIMR Berghofer Medical Research Institute, Herston, Australia.
Anticancer Research
|April 30, 2016
Summary
Vitamin D receptor (VDR) gene variations may influence skin cancer risk. Specific VDR polymorphisms were linked to reduced risk of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).
Area of Science:
- Dermatology
- Genetics
- Cancer Research
Background:
- The vitamin D endocrine system plays a role in skin carcinogenesis.
- Genetic variations in the vitamin D receptor (VDR) gene may impact keratinocyte cancer risk.
Purpose of the Study:
- To investigate the association between VDR-related pathway polymorphisms and keratinocyte cancers (BCC and SCC).
Main Methods:
- A nested case-control study of 1,124 adults over 11 years.
- Multivariate regression analysis and meta-analysis of specific VDR polymorphisms (rs2228570, rs7975232, rs1544410, rs739837).
Main Results:
- Specific genotypes (rs2228570, rs927650) showed decreased SCC risk.
- Meta-analysis revealed lower SCC risk with rs1544410 recessive genotypes.
- Rs7975232 and rs739837 recessive genotypes were associated with decreased BCC risk.
Conclusions:
- Vitamin D receptor gene polymorphisms are potentially associated with keratinocyte cancer risk.
- Findings suggest a link between VDR variations and susceptibility to BCC and SCC.
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