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Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Published on: November 2, 2014
Molecular Imaging of Ovarian Cancer
Sai Kiran Sharma1, Brandon Nemieboka2, Evis Sala3
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.
Abstract:
Ovarian cancer is the most lethal gynecologic malignancy and the fifth leading cause of cancer-related death in women. Over the past decade, medical imaging has played an increasingly valuable role in the diagnosis, staging, and treatment planning of the disease. In this "Focus on Molecular Imaging" review, we seek to provide a brief yet informative survey of the current state of the molecular imaging of ovarian cancer. The article is divided into sections according to modality, covering recent advances in the MR, PET, SPECT, ultrasound, and optical imaging of ovarian cancer. Although primary emphasis is given to clinical studies, preclinical investigations that are particularly innovative and promising are discussed as well. Ultimately, we are hopeful that the combination of technologic innovations, novel imaging probes, and further integration of imaging into clinical protocols will lead to significant improvements in the survival rate for ovarian cancer.
Insights
Molecular imaging is advancing ovarian cancer diagnosis and treatment. Innovations in MRI, PET, SPECT, ultrasound, and optical imaging show promise for improving patient survival rates.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Ovarian cancer is a leading cause of cancer death in women.
- Medical imaging is crucial for ovarian cancer diagnosis, staging, and treatment planning.
Purpose of the Study:
- To review current advancements in molecular imaging for ovarian cancer.
- To cover various imaging modalities including MR, PET, SPECT, ultrasound, and optical imaging.
Main Methods:
- Review of clinical and preclinical studies on ovarian cancer molecular imaging.
- Categorization of advances by imaging modality.
Main Results:
- Significant progress has been made across multiple imaging techniques.
- Both clinical applications and promising preclinical research are highlighted.
Conclusions:
- Technological innovations and novel imaging probes are key.
- Integration of advanced imaging into clinical protocols may improve survival rates for ovarian cancer.
