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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Concentric Polycyclic Regrowth Pattern in Alopecia Areata.

Lilian Mathias Delorenze1, Maria Fernanada Reis Gavazzoni-Dias1, Marcelo S Teixeira1

  • 1Department of Dermatology, Universidade Federal Fluminense, Niterói, Brasil.

International Journal of Trichology
|April 30, 2016
PubMed
Summary

Alopecia areata, an autoimmune hair loss condition, can rarely present with unusual regrowth patterns. This case highlights concentric targetoid hair regrowth, a rare phenomenon in alopecia areata.

Keywords:
Alopecia areatacorticosteroid treatmenthair disorderhair regrowth

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Area of Science:

  • Dermatology
  • Autoimmune diseases
  • Hair follicle biology

Background:

  • Alopecia areata (AA) is a prevalent autoimmune condition causing nonscarring hair loss.
  • Atypical hair regrowth, including specific patterns and color changes, is infrequently observed in AA patients.
  • Understanding these rare phenomena is crucial for comprehensive AA management.

Observation:

  • This report details a rare case of alopecia areata exhibiting concentric targetoid hair regrowth.
  • The patient presented with a unique pattern of hair restoration, deviating from typical regrowth observed in AA.
  • The concentric targetoid pattern suggests specific underlying mechanisms in hair follicle response.

Findings:

  • The case study documents a specific instance of concentric targetoid regrowth in alopecia areata.
  • This finding contributes to the limited literature on atypical hair regrowth patterns in AA.
  • The observed regrowth pattern may offer insights into the pathophysiology of alopecia areata.

Implications:

  • This case underscores the diverse clinical presentations of alopecia areata.
  • Further research into the mechanisms behind atypical regrowth patterns like concentric targetoid regrowth is warranted.
  • Such findings can potentially refine diagnostic criteria and therapeutic strategies for alopecia areata.