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Updated: Dec 30, 2025

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Multisystem reactions during egg oral food challenges may be associated with less severe reactions on initial
Girish Vitalpur1, Ann Esquivel2, Kirsten M Kloepfer1
1Department of Pediatrics, Indiana University School of Medicine, 705 Riley Hospital Drive, ROC 4270, Indianapolis, IN 46202 USA.
Abstract:
In this study, we assessed whether multisystem reactions to egg and extensively-heated (EH) egg during OFCs were associated with a history of multisystem reactions. Records of children, who underwent OFC to egg or EH egg over a five-year period were reviewed. Of the 120 challenges, 26 (21.67 %) failed, with 38.4 % (10/26) having multisystem reactions. Of the 13 who had multisystem reactions on initial presentation, only two (15.4 %) had a similar OFC outcome. Eighty percent (8/10) of those who had a multisystem OFC reaction had a less severe initial presentation. Initial and OFC multisystem reactions were not associated with each other.
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