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Updated: Mar 22, 2026
Procurement of Parathyroid Glands from Living Donor Pigs and Ex Vivo Identification
Published on: August 1, 2025
Use of the gamma probe to identify multigland disease in primary hyperparathyroidism
Kirby Tobin1, Rachel R Ayers1, Mohammad Rajaei1
1Department of Surgery, University of Wisconsin, K3/739 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA.
Aim:
The purpose of this study was to determine threshold gamma probe counts to distinguish single adenoma (SA) from multigland disease (MGD) during radioguided parathyroidectomy.
Methods:
A retrospective analysis of 1656 patients was performed. Ex vivo counts of the first excised gland were taken and recorded as a percentage of background counts.
Results:
69.4% of MGD patients had counts below the 50% threshold. The 50% threshold correctly grouped 72.8% of our cohort. Counts of more than 100% were accurate for grouping SA, with only 6.8% of patients with counts more than 100% having MGD.
Conclusions:
The gamma probe can aid surgeons in deciding to continue neck exploration if MGD is suspected or wait for labs to confirm cure if SA is suspected.
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