Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Erythrocyte agglutination in microgravity.

R T Morehead1, T A Olsen, E H Drake

  • 1Wausau Hospital Center, WI 54401.

Aviation, Space, and Environmental Medicine
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The roentgen and cardiac manifestations of funnel chest.

The American journal of roentgenology and radium therapy·2010
Same author

Therapeutic doses of vitamin B12 give false-positive values for intrinsic-factor-blocking antibodies.

Clinical chemistry·1984
Same author

Transventricular revascularization by laser.

Lasers in surgery and medicine·1982
Same author

Wrongful discharge claims raised by at will employees: a new legal concern for employers.

Labor law journal·1981
Same author

Hypertension screening of adolescents in Central Wisconsin-a Ward Ford Memorial Institute.

Wisconsin medical journal·1980
Same author

Laser therapy of rheumatoid arthritis.

Lasers in surgery and medicine·1980
Same journal

Goodbye to ASEM.

Aviation, space, and environmental medicine·2014
Same journal

AsMA - a worldwide organization.

Aviation, space, and environmental medicine·2014
Same journal

This month in aerospace medicine history.

Aviation, space, and environmental medicine·2014
Same journal

You're the flight surgeon: hypogonadism.

Aviation, space, and environmental medicine·2014
Same journal

You're the flight surgeon: fatigue.

Aviation, space, and environmental medicine·2014
Same journal

Manned-unmanned teaming: expanding the envelope of UAS operational employment.

Aviation, space, and environmental medicine·2014
See all related articles

Blood grouping tests, including ABO and Coombs, function in microgravity using a novel device. This demonstrates the feasibility of clinical laboratory examinations in space.

Area of Science:

  • Space Medicine
  • Clinical Pathology
  • Biotechnology

Background:

  • Gravity's influence on biological reactions is not fully understood.
  • Microgravity presents unique challenges for diagnostic testing.
  • Previous blood grouping methods were not adapted for spaceflight.

Purpose of the Study:

  • To evaluate a self-contained blood grouping device in microgravity.
  • To determine if gravity affects blood grouping reactions.
  • To assess the feasibility of space-based clinical laboratory diagnostics.

Main Methods:

  • A self-contained device was developed for agglutination and collection of agglutinates.
  • The device was tested on the Columbia Space Shuttle under microgravity.
  • Human erythrocytes (Rh, ABO, Coombs-sensitized) were tested against antisera and diluents.

Related Experiment Videos

Main Results:

  • The device successfully produced agglutinates for ABO and Coombs-sensitized blood groups.
  • Rh test and control systems failed due to crystallization.
  • Agglutinates were collected on filter paper for post-flight analysis.

Conclusions:

  • ABO and Coombs-sensitized blood grouping tests are viable in microgravity.
  • Microgravity may result in smaller agglutinate formation compared to full gravity.
  • A closed system for clinical laboratory examination in space has been successfully demonstrated.