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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Mar 22, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

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A Combination Approach to Surgical Scars.

Robert E Eilers1, Edward Victor Ross, Joel L Cohen

  • 1*Department of Dermatology, University of California San Diego, San Diego, California; †Scripps Clinic, Laser and Cosmetic Dermatology, San Diego, California; ‡Department of Dermatology, University of Colorado, Boulder, Colorado.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|April 30, 2016
PubMed
Summary

Surgical scar revision is best achieved with combination treatments. This study proposes a treatment algorithm for effectively combining various scar revision techniques for improved cosmetic outcomes.

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Area of Science:

  • Dermatology
  • Plastic Surgery
  • Aesthetic Medicine

Background:

  • Scar formation is an unavoidable surgical risk.
  • Despite preventive measures, some patients seek scar revision for improved cosmesis.
  • Surgical and laser scar revision techniques are continually evolving.

Purpose of the Study:

  • To propose a treatment algorithm for surgical scar revision.
  • To guide the use of combination treatments for optimal results.
  • To provide a structured approach to managing diverse scar types.

Main Methods:

  • Comprehensive PubMed literature search on surgical scar revision techniques.
  • Inclusion of authors' clinical experience and personal insights.
  • Review of various treatment modalities, including surgical, injection, and energy-based devices.

Main Results:

  • Identified multiple scar revision techniques: surgical excision, intralesional injections (corticosteroids, 5-fluorouracil), and various laser treatments (PDT, fractional ablative/nonablative).
  • Microneedling and fractional needle radiofrequency also noted as effective modalities.
  • Clinical photographs demonstrate scar appearance improvement with isolated and combination treatments.

Conclusions:

  • Combination treatment approaches are superior for addressing multifaceted surgical scars.
  • The proposed algorithm offers guidance on safe and effective combination therapy.
  • Optimizing scar cosmesis requires a tailored, multi-modal strategy.