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Updated: Mar 22, 2026

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Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
Published on: April 28, 2022
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A Combination Approach to Surgical Scars
Robert E Eilers1, Edward Victor Ross, Joel L Cohen
1*Department of Dermatology, University of California San Diego, San Diego, California; †Scripps Clinic, Laser and Cosmetic Dermatology, San Diego, California; ‡Department of Dermatology, University of Colorado, Boulder, Colorado.
Summary
Surgical scar revision is best achieved with combination treatments. This study proposes a treatment algorithm for effectively combining various scar revision techniques for improved cosmetic outcomes.
Area of Science:
- Dermatology
- Plastic Surgery
- Aesthetic Medicine
Background:
- Scar formation is an unavoidable surgical risk.
- Despite preventive measures, some patients seek scar revision for improved cosmesis.
- Surgical and laser scar revision techniques are continually evolving.
Purpose of the Study:
- To propose a treatment algorithm for surgical scar revision.
- To guide the use of combination treatments for optimal results.
- To provide a structured approach to managing diverse scar types.
Main Methods:
- Comprehensive PubMed literature search on surgical scar revision techniques.
- Inclusion of authors' clinical experience and personal insights.
- Review of various treatment modalities, including surgical, injection, and energy-based devices.
Main Results:
- Identified multiple scar revision techniques: surgical excision, intralesional injections (corticosteroids, 5-fluorouracil), and various laser treatments (PDT, fractional ablative/nonablative).
- Microneedling and fractional needle radiofrequency also noted as effective modalities.
- Clinical photographs demonstrate scar appearance improvement with isolated and combination treatments.
Conclusions:
- Combination treatment approaches are superior for addressing multifaceted surgical scars.
- The proposed algorithm offers guidance on safe and effective combination therapy.
- Optimizing scar cosmesis requires a tailored, multi-modal strategy.

