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Published on: April 11, 2016
12.3K
Precision Medicine in Gastrointestinal Pathology
1From the Department of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, Dallas (Dr Wang);
Archives of Pathology & Laboratory Medicine
|April 30, 2016
Summary
Precision medicine aims to personalize cancer care by matching tumor genetic variants with targeted therapies. Gastrointestinal oncology shows mixed results, highlighting the need for genomic testing quality and trial design improvements.
Area of Science:
- Oncology
- Genomics
- Precision Medicine
Background:
- Precision medicine offers individualized patient management based on personal biology.
- Global initiatives like the Million Veteran Program and Precision Medicine Initiative underscore the drive for large-scale genomic sequencing.
- Implementing precision medicine in oncology requires matching tumor genetic variants with effective clinical therapeutics.
Purpose of the Study:
- To review the current status of precision medicine in gastrointestinal oncology.
- To discuss available targeted therapeutics and novel findings in clinical genomic oncology.
- To address quality issues in genomic testing and explore emerging clinical trial designs.
Main Methods:
- Literature review of clinical genomic studies in gastrointestinal malignancies.
- Analysis of clinical oncology trials for therapeutics targeting molecular alterations.
- Examination of emerging clinical oncology study designs.
Main Results:
- Gastrointestinal oncology demonstrates a history of both successes and failures in precision medicine applications.
- Available targeted therapeutics and promising genomic findings are presented.
- Quality issues in genomic testing and novel clinical trial designs are discussed.
Conclusions:
- Translating genomic sequencing capabilities into improved patient survival is a key challenge for the coming decade.
- Further advancements in precision medicine are needed for meaningful clinical impact in gastrointestinal malignancies.
