Cardiac gene therapy: are we there yet?

Area of Science:

• Cardiovascular Research
• Molecular Medicine
• Gene Therapy

Background:

• Cardiovascular disease (CVD) incidence and mortality are rising globally.
• Pharmacotherapies offer limited benefits for cardiac dysfunction.
• Gene therapy is emerging as a key alternative treatment modality.

Purpose of the Study:

• To review gene therapy advancements for cardiovascular disease.
• To summarize gene delivery systems, targets, and clinical studies.
• To discuss limitations and future directions for CVD gene therapy.

Main Methods:

• Review of preclinical and clinical studies on gene therapy for CVD.
• Analysis of gene delivery carriers and modes of administration.
• Identification of molecular targets for CVD intervention.

Main Results:

• Gene therapy has demonstrated therapeutic efficiency in various CVD models and patients.
• Advances in vectors and delivery systems facilitate targeted molecular interventions.
• Several potential therapeutic targets for CVD have been identified.

Conclusions:

• Gene therapy holds significant potential as an unconventional treatment for CVD.
• Overcoming limitations in gene carriers and delivery systems is crucial.
• Continued research will advance the clinical application of gene therapy for cardiovascular patients.