Intraventricular temperature measured by diffusion-weighted imaging compared with brain parenchymal temperature
Kaoru Sumida1,2, Noriko Sato1, Miho Ota3
1Department of Radiology, National Center Hospital of Neurology and Psychiatry, Tokyo, Japan.
Abstract:
We examined and compared the temperatures of the intraventricular cerebrospinal fluid (Tv ) and the brain parenchyma (Tp ) using MRI, with reference to the tympanic membrane temperature (Tt ) in healthy subjects. We estimated Tv and Tp values from data gathered simultaneously by MR diffusion-weighted imaging (DWI) and MRS, respectively, in 35 healthy volunteers (17 males, 18 females; age 25-78 years). We also obtained Tt values just before each MR examination to evaluate the relationships among the three temperatures. There were significant positive correlations between Tv and Tp (R = 0.611, p < 0.001). The correlation was also significant after correction for Tt (R = 0.642, p < 0.001). There was no significant correlation between Tv and Tt or between Tp and Tt in the men or the women. Negative correlations were found between Tv and age and between Tp and age in the males but not females. DWI thermometry seems to reflect the intracranial environment as accurately as MRS thermometry. An age-dependent decline in temperature was evident in our male subjects by both DWI and MRS thermometry, probably due to the decrease in cerebral metabolism with age. Copyright © 2016 John Wiley & Sons, Ltd.
Insights
This study found that intraventricular cerebrospinal fluid temperature and brain parenchyma temperature correlate well in healthy adults. DWI thermometry accurately reflects the intracranial environment, showing an age-dependent temperature decline in males.
Area of Science:
- Neuroimaging
- Medical Physics
- Physiology
Background:
- Accurate measurement of intracranial temperature is crucial for understanding brain physiology and pathology.
- Previous methods for measuring brain temperature have limitations in precision and invasiveness.
Purpose of the Study:
- To compare the accuracy of MR diffusion-weighted imaging (DWI) and MR spectroscopy (MRS) for measuring intraventricular cerebrospinal fluid (Tv) and brain parenchyma (Tp) temperatures.
- To investigate the relationship between Tv, Tp, and tympanic membrane temperature (Tt) in healthy subjects.
- To explore potential age- and sex-related differences in intracranial temperatures.
Main Methods:
- Simultaneous estimation of Tv and Tp using DWI and MRS, respectively, in 35 healthy volunteers.
- Measurement of tympanic membrane temperature (Tt) immediately before MRI scans.
- Statistical analysis to determine correlations between Tv, Tp, Tt, age, and sex.
Main Results:
- Significant positive correlations were observed between Tv and Tp (R=0.611, p<0.001), which persisted after correction for Tt (R=0.642, p<0.001).
- No significant correlation was found between Tv and Tt, or between Tp and Tt, in either sex.
- Negative correlations between Tv and age, and Tp and age, were observed in males but not females, suggesting an age-dependent decline in temperature in males.
Conclusions:
- DWI thermometry provides an accurate assessment of the intracranial environment, comparable to MRS thermometry.
- Intracranial temperatures (Tv and Tp) are closely related and independent of peripheral temperature (Tt).
- An age-dependent decrease in brain temperature, potentially linked to reduced cerebral metabolism, is evident in males.
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