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Updated: Mar 22, 2026

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
Published on: January 7, 2020
Music therapy can lower the heart rates of severely sick children
L Uggla1,2,3, L O Bonde4, B M Svahn5
1Astrid Lindgren Children's Hospital, Karolinska University Hospital-Huddinge, Stockholm, Sweden. lena.uggla@ki.se.
Insights
Music therapy significantly reduced heart rates in children undergoing haematopoietic stem cell transplants (HSCT). This intervention shows promise for alleviating stress and potentially lowering the risk of post-traumatic stress disorder (PTSD) in these young patients.
Area of Science:
- Pediatric Hematology/Oncology
- Integrative Medicine
- Psychoneuroimmunology
Background:
- Children undergoing hematopoietic stem cell transplants (HSCT) face a heightened risk of developing post-traumatic stress disorder (PTSD).
- Effective stress-alleviation strategies are crucial for this vulnerable pediatric population.
Purpose of the Study:
- To investigate the impact of music therapy on physiological stress indicators in pediatric HSCT patients.
- To compare the effects of music therapy versus standard care in children undergoing HSCT.
Main Methods:
- A randomized clinical pilot study involving 24 pediatric patients (up to 16 years) undergoing HSCT.
- The intervention group received twice-weekly music therapy (expressive and receptive elements).
- The control group received standard care; physiological parameters were monitored.
Main Results:
- Music therapy significantly reduced evening heart rates in the treatment group compared to controls (p < 0.001).
- The heart rate reduction was sustained for 4–8 hours post-intervention.
- No significant differences in blood pressure or oxygen saturation were observed between groups.
Conclusions:
- Music therapy effectively lowers heart rate in pediatric HSCT patients for several hours, indicating reduced physiological stress.
- This intervention may serve as a valuable tool in mitigating PTSD risk in children post-transplant.
- Further research into music therapy's role in pediatric transplant care is warranted.
Aim:
Paediatric recipients of haematopoietic stem cell transplants (HSCT) are at increased risk of developing post-traumatic stress disorder (PTSD), and there is a need to identify interventions that can alleviate stress in this group. The aim of this study was to examine the previously unexplored effect of music therapy on children undergoing HSCT, by analysing physiological parameters and comparing them with a control group.
Methods:
We performed a randomised clinical pilot study of 24 patients up to the age of 16 undergoing HSCT at Karolinska University Hospital, Huddinge, Sweden. Music therapy, including expressive and receptive elements, was performed twice a week in the treatment group and compared to standard care in the control group. Physiological parameters were evaluated according to the hospital's protocols.
Results:
The music therapy group had significantly reduced evening heart rates compared to the control group (p < 0.001), and the effect was sustainable for four to eight hours after the intervention. There were no significant differences in saturation or blood pressure observed between the groups.
Conclusion:
Music therapy significantly lowered the heart rate of children undergoing HSCT for at least four to eight hours, indicating reduced stress levels and potentially lowering the risk of developing PTSD.
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