Related Experiment Video
Updated: Dec 25, 2025

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
Published on: December 16, 2022
Metabolic control of food intake
Abstract:
A specific biochemical mechanism for the metabolic control of food intake has not been identified. However, a theory based on a signal generated from the oxidation of metabolic fuels and detected in the liver offers a powerful, integrative framework that helps explain a number of phenomena related to feeding behavior. In addition to providing a metabolic basis for the formation of conditioned food flavor preferences, a control of food intake by fuel oxidation provides a mechanism for overeating in the dynamic phase of obesity and hyperphagia produced by high-fat diets.
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