Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

Antihypertensive Drugs: Angiotensin II Receptor Blockers

3.0K
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
3.0K
Renal Drug Excretion: Tubular Secretion01:28

Renal Drug Excretion: Tubular Secretion

1.1K
Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
1.1K
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

2.6K
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
2.6K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

1.4K
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.4K
Renal Drug Excretion: Overview01:15

Renal Drug Excretion: Overview

930
As primary excretory organs, the kidneys maintain homeostasis by removing waste substances from the bloodstream. They comprise over a million units called nephrons, which serve as the kidney's functional units.
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
930
Renal Drug Excretion: Tubular Reabsorption01:25

Renal Drug Excretion: Tubular Reabsorption

1.0K
Tubular reabsorption, a process occurring post-glomerular filtration of drugs in the renal tubule, is a critical determinant of drug half-life. During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. This...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ischemic injury of the upper gastrointestinal tract after out-of-hospital cardiac arrest: a prospective, multicenter study.

Critical care (London, England)·2022
Same author

[Enteropathy due to olmesartan].

Annales de cardiologie et d'angeiologie·2015
Same author

Olmesartan-associated enteropathy: results of a national survey.

Alimentary pharmacology & therapeutics·2014
Same author

[Hepatitis B reactivation with rituximab in an HIV-infected anti-HBs antibody carrier].

Medecine et maladies infectieuses·2011
Same author

[Gastric metastasis revealing lung cancer].

Gastroenterologie clinique et biologique·2009
Same author

[HCV contamination of endoscopes and biopsy clips].

Annales de biologie clinique·2001
Same journal

[Study of Sleep Apnea Syndrome in Patients with Chronic Heart Failure in the Cardiology Department at Yalgado Ouédraogo teaching hospital in 2024 and 2025].

Annales de cardiologie et d'angeiologie·2026
Same journal

[Impact of knowledge and practices of hygieno-dietetical measures in hypertensive people at the Abidjan cardiology institute].

Annales de cardiologie et d'angeiologie·2026
Same journal

[Correlation between carotid atheroma and DAS28 gamma GT score in rheumatoid arthritis in an African black population].

Annales de cardiologie et d'angeiologie·2026
Same journal

[Dobutamine stress echocardiography: Appropriateness of indications and protocol compliance. A single-centre report].

Annales de cardiologie et d'angeiologie·2026
Same journal

[Post-COVID postural orthostatic tachycardia syndrome: Documentation of a hyperadrenergic phenotype by comprehensive autonomic testing].

Annales de cardiologie et d'angeiologie·2026
Same journal

Urban-rural disparities in hypertension prevalence, screening, and control in South Kivu Province, eastern Democratic Republic of the Congo.

Annales de cardiologie et d'angeiologie·2026
See all related articles

Related Experiment Video

Updated: Mar 22, 2026

Investigation of Xenobiotics Metabolism In Salix alba Leaves via Mass Spectrometry Imaging
09:21

Investigation of Xenobiotics Metabolism In Salix alba Leaves via Mass Spectrometry Imaging

Published on: June 15, 2020

3.6K

[Enteropathy due to olmesartan].

M Ould Sidi Mohamed1, P Colardelle2

  • 1N̊ 72, lot HAJ Slimane, Bouitat, Yacoub Elmansour, 10050 Rabat, Maroc.

Annales De Cardiologie Et D'Angeiologie
|May 1, 2016
PubMed
Summary
This summary is machine-generated.

Olmesartan, a hypertension medication, can cause serious gastrointestinal issues like villous atrophy and chronic diarrhea. Stopping the drug led to rapid symptom improvement, confirming olmesartan-induced enteropathy.

Keywords:
EnteropathyEntéropathiesOlmesartanOlmésartan

More Related Videos

Targeting the Rat's Small Bowel: Long-Term Infusion into the Superior Mesenteric Artery
07:12

Targeting the Rat's Small Bowel: Long-Term Infusion into the Superior Mesenteric Artery

Published on: April 8, 2021

5.3K
Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

1.0K

Related Experiment Videos

Last Updated: Mar 22, 2026

Investigation of Xenobiotics Metabolism In Salix alba Leaves via Mass Spectrometry Imaging
09:21

Investigation of Xenobiotics Metabolism In Salix alba Leaves via Mass Spectrometry Imaging

Published on: June 15, 2020

3.6K
Targeting the Rat's Small Bowel: Long-Term Infusion into the Superior Mesenteric Artery
07:12

Targeting the Rat's Small Bowel: Long-Term Infusion into the Superior Mesenteric Artery

Published on: April 8, 2021

5.3K
Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

1.0K

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Olmesartan is a widely prescribed angiotensin II receptor blocker for essential hypertension.
  • Gastrointestinal side effects of olmesartan, though rare, are increasingly recognized.

Observation:

  • A patient developed chronic diarrhea and significant weight loss after three years of olmesartan use.
  • Endoscopic and histological examination revealed duodenal villous atrophy, lymphocytic infiltrate, and erosive esophagitis.

Findings:

  • Reintroduction of olmesartan precipitated immediate symptom recurrence, strongly implicating the drug.
  • Biopsies confirmed inflammatory changes, including epithelial lymphocytosis and villous atrophy, consistent with olmesartan-induced enteropathy.

Implications:

  • This case highlights the importance of considering olmesartan-induced enteropathy in patients with unexplained gastrointestinal symptoms.
  • Early recognition and drug discontinuation are crucial for favorable patient outcomes and preventing further complications.