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Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
Published on: May 4, 2020
Clinical applications of HPLC-ICP-MS element speciation: A review
Jeany Delafiori1, Gavin Ring2, Ambrose Furey2
1School of Pharmaceutical Sciences, University of Campinas, 13083-859 Campinas, São Paulo, Brazil; Mass Spectrometry research groups, Department of Physical Sciences, Cork Institute of Technology, Rossa Avenue, Co. Cork, Bishopstown, Ireland; CAPES Foundation, Ministry of Education of Brazil, 70040-020 Brasilia, Federal District Brazil.
Abstract:
Arsenic (As), Selenium (Se) and Mercury (Hg) are three trace elements that have been the subject of much analytical discussion and investigation over the last three decades. While Selenium (Se) is among the list of essential trace elements necessary for the regulation of metabolic processes and overall health, As and Hg are not, and have been the centre of various cases surrounding the contamination of food, water and the environment. The focus of this review is to explore the area of chemical speciation, particularly as it relates to the measurement of these elements in various clinical matrices by HPLC-ICP-MS. This review will highlight the importance of accurately identifying the various chemical species of each of these elements, especially when considering their respective toxicological impacts on human health.
