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Related Experiment Video

Updated: Mar 22, 2026

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
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Microfluidic-based generation of functional microfibers for biomimetic complex tissue construction.

Yicong Zuo1, Xiaoheng He2, You Yang1

  • 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610065, People's Republic of China.

Acta Biomaterialia
|May 1, 2016
PubMed
Summary

This study developed composite microfibers using methacrylated gelatin and alginate for tissue engineering. These microfibers enable precise control over structure and support cell growth, showing promise for complex tissue regeneration.

Keywords:
AlginateMethacrylated gelatinMicrofibersMicrofluidicOsteon

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Microfluidics

Background:

  • Reconstructing complex tissues requires advanced biomaterials for fiber fabrication.
  • Existing materials often lack the necessary mechanical properties, biocompatibility, or microenvironmental control for cell survival and function.
  • Microfluidic systems offer potential for engineered tissue fabrication but require suitable composite materials.

Purpose of the Study:

  • To engineer composite microfibers using methacrylated gelatin (GelMA) and alginate for microfluidic-based tissue reconstruction.
  • To investigate the mechanical properties and biocompatibility of the composite hydrogels.
  • To demonstrate the fabrication of double-layer hollow microfibers and their application in creating biomimetic tissue structures.

Main Methods:

  • Fabrication of composite hydrogels by combining GelMA and alginate.
  • Utilizing a capillary microfluidic device for precise control over microfiber dimensions and structure.
  • Encapsulating human umbilical vascular endothelial cells (HUVECs) and human osteoblast-like cells (MG63) within double-layer hollow microfibers.
  • Assessing cell viability, growth, and gene expression post-encapsulation.

Main Results:

  • GelMA incorporation enhanced mechanical moduli, stretching performance, and reduced swelling of alginate hydrogels.
  • Double-layer hollow microfibers with controlled size and multi-layered structures were successfully fabricated.
  • A biomimetic osteon-like structure with encapsulated HUVECs and MG63 cells demonstrated robust cell growth and up-regulated gene expression.
  • The microfibers showed suitability for woven-structure assembly.

Conclusions:

  • The developed microfluidic-based composite microfibers offer a promising platform for complex tissue regeneration.
  • The combination of GelMA and alginate provides tunable mechanical properties and biocompatibility for engineered tissues.
  • This system advances microfluidic technology applications in biofabrication, biomaterials, and tissue engineering.