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Neuroinflammation Regulates Cognitive Impairment in Socially Defeated Mice
Madeline L Pfau1, Scott J Russo2
1Fishberg Department of Neuroscience and Friedman Brain Institute; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, NY, NY 10029, USA.
Trends in Neurosciences
|May 1, 2016
Abstract:
Impairments in memory and cognitive function are characteristic symptoms of stress-related disorders, but the relationship between stress and memory is complex. Recent findings suggest that hippocampal inflammatory processes contribute to spatial memory deficits in the rodent social defeat model that can be reversed by anti-inflammatory treatment with minocycline.
