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Adverse Drug Reactions Associated with Ceftaroline Use: A 2-Center Retrospective Cohort

Kimberly G Blumenthal1, James L Kuhlen2, Ana A Weil3

  • 1Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass; Department of Medicine, Harvard Medical School, Boston, Mass; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Mass.

The Journal of Allergy and Clinical Immunology. in Practice
|May 1, 2016
PubMed
Abstract

Insights

Ceftaroline is used for infections beyond skin and pneumonia. This study found a high rate of adverse drug reactions (ADRs), including severe hypersensitivity reactions (HSRs), indicating a need for further research.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Clinical Pharmacy

Background:

  • Ceftaroline fosamil is a cephalosporin antibiotic approved for treating skin and soft tissue infections (SSTIs) and community-acquired pneumonia (CAP).
  • Its use extends to infections caused by methicillin-resistant Staphylococcus aureus (MRSA).

Observation:

  • A retrospective review of 96 inpatients receiving ceftaroline between May 2012 and February 2015 was conducted.
  • The study analyzed diagnosed adverse drug reactions (ADRs), including hypersensitivity reactions (HSRs).
  • Risk factors for ADRs were identified.

Findings:

  • Ceftaroline was administered for various infections, with 54% of patients treated for MRSA.
  • 21% of patients experienced ADRs, most commonly hematologic (15) and cutaneous (9) findings.
  • Severe HSRs were observed, and patients with ADRs received more ceftaroline doses (median 46 vs 21).
  • No increased risk of ADRs was associated with a history of beta-lactam allergy.

Implications:

  • Ceftaroline's clinical utility extends beyond its approved indications.
  • A significant rate of ADRs, including severe HSRs, was observed.
  • Further research is necessary to elucidate the frequency and predictors of ceftaroline-associated ADRs and HSRs.
Keywords:
Adverse drug reactionCeftarolineDrugHypersensitivityallergybeta-lactam

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