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The influence of experimental conditions on the spectrin-hemoglobin interaction
J Vincentelli1, A Fraboni, C Paul
1Laboratoire de Chimie Générale I, Université libre de Bruxelles.
Biological Chemistry Hoppe-Seyler
|January 1, 1989
Abstract:
Human spectrin, when isolated, purified and stored in such conditions that preserve its tetrameric form, is able to associate with human hemoglobin as it is clearly shown by gel filtration. However, this hemoglobin-spectrin association does not seem to have a significant effect on hemoglobin oxygenation as indicated by equilibrium and rapid kinetics measurements.