LassoProt: server to analyze biopolymers with lassos.

Area of Science:

• Biophysics
• Computational Biology
• Polymer Physics

Background:

• Biopolymers can adopt complex entangled configurations known as lassos.
• Understanding these lasso structures is crucial for various scientific disciplines.

Purpose of the Study:

• To introduce the LassoProt server for analyzing biopolymer lasso configurations.
• To provide tools for visualizing lasso structures and their time trajectories.
• To establish a database of proteins with complex lassos.

Main Methods:

• Development and validation of the LassoProt server.
• Analysis of biopolymer configurations using computational methods.
• Creation of a comprehensive database by processing the Protein Data Bank (PDB).

Main Results:

• The LassoProt server offers diverse visualization options for lasso configurations and time trajectories.
• All analysis results and plots are downloadable for further use.
• A validated database of proteins with complex lassos, enriched with biological data, has been generated.

Conclusions:

• LassoProt serves as a valuable tool for biologists, biophysicists, chemists, polymer physicists, and mathematicians.
• The generated database can be utilized for studying protein geometry, entanglement-function correlations, and protein modeling.
• The server facilitates the exploration of complex biopolymer structures and their implications.