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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Related Experiment Video

Updated: Mar 21, 2026

Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules

Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules

Published on: August 16, 2011

A next-generation proteome array for Schistosoma mansoni.

Rafael Ramiro de Assis¹, Fernanda Ludolf², Rie Nakajima³

¹Laboratório de Imunologia Celular e Molecular, Instituto Rene Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil; Protein Microarray Laboratory, Division of Infectious Disease, School of Medicine, University of California, Irvine, CA, USA.

International Journal for Parasitology

|May 2, 2016

Summary

This summary is machine-generated.

Researchers created a Schistosoma mansoni proteome microarray to identify antibody signatures for schistosomiasis stages and potential vaccine candidates. The pilot study confirmed the microarray

Keywords:

Antibody signature Protein microarray Proteome Schistosoma mansoni

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Published on: December 12, 2017

Area of Science:

Parasitology and immunology
Proteomics and bioinformatics
Vaccine development

Background:

Schistosomiasis is a major parasitic disease caused by Schistosoma mansoni.
Understanding host immune responses is crucial for schistosomiasis control and vaccine design.
A comprehensive proteome microarray is a valuable tool for dissecting host-parasite interactions.

Purpose of the Study:

To develop and validate a Schistosoma mansoni proteome microarray.
To identify specific antibody signatures associated with acute and chronic schistosomiasis.
To discover potential subunit vaccine candidates.

Main Methods:

Selection of 992 Schistosoma mansoni proteins representing ~10% of the predicted proteome.
Production and screening of a proteome microarray using sera from infected individuals.
Analysis of antibody responses in individuals from endemic (Brazil) and non-endemic (USA) areas.

Main Results:

The proteome microarray successfully detected differential antibody responses.
Distinct antibody signatures were observed between acute and chronic schistosomiasis patients.
The array demonstrated functionality and informativeness for diagnostic and vaccine discovery.

Conclusions:

The Schistosoma mansoni proteome microarray is a powerful tool for schistosomiasis research.
Antibody profiling can distinguish clinical stages of schistosomiasis.
The identified proteins are potential candidates for subunit vaccine development.