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Related Experiment Video

Updated: Mar 21, 2026

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

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Published on: March 15, 2024

Reward Processing and Risk for Depression Across Development.

Katherine R Luking¹, David Pagliaccio², Joan L Luby³

¹Department of Psychology, Stony Brook University, Stony Brook, NY 11794, USA.

Trends in Cognitive Sciences

|May 2, 2016

Summary

This summary is machine-generated.

Adolescents with major depressive disorder (MDD) show a blunted striatal response to reward. Early intervention is crucial before MDD onset increases in adolescence.

Keywords:

depression development.reward

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Area of Science:

Neuroscience
Developmental Psychology
Psychopathology

Background:

Striatal response to reward is critical in typical adolescent development.
Adolescents with major depressive disorder (MDD) and those at high risk exhibit blunted striatal reward responses.

Purpose of the Study:

To review findings on blunted striatal response to reward in MDD risk.
To contextualize these findings within adolescent development.
To identify needs for future research.

Main Methods:

Literature review of studies on striatal reward response in typical development and MDD.
Analysis of existing research on MDD risk and reward processing.

Main Results:

Typically developing adolescents show robust striatal reward response.
Adolescents with MDD and high-risk adolescents display a blunted striatal response to reward.

Conclusions:

Understanding the intersection of blunted reward response and MDD risk is vital for early intervention.
Future research should investigate longitudinal development, MDD specificity, and moderating/mediating factors.