Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.7K
1.7K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.3K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
Autophagy01:27

Autophagy

6.1K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
6.1K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.3K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recognition kinetics of biomolecules at the surface of different-sized spheres.

Biophysical journal·2014
Same author

A supercharged fluorescent protein as a versatile probe for homogeneous DNA detection and methylation analysis.

Angewandte Chemie (International ed. in English)·2014
Same author

Radiation-induced removal of sulphadiazine antibiotics from wastewater.

Environmental technology·2014
Same author

Effect of Methyl-CpG binding domain protein 2 (MBD2) on AMD-like lesions in ApoE-deficient mice.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban·2014
Same author

Overexpression of TRPM7 is associated with poor prognosis in human ovarian carcinoma.

Asian Pacific journal of cancer prevention : APJCP·2014
Same author

The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.

The Journal of biological chemistry·2014

Related Experiment Video

Updated: Mar 21, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

900

Autophagy as a target for hematological malignancy therapy.

Zhiwu Dong1, Shuang Liang1, Jun Hu1

  • 1Department of Laboratory Medicine, Jinshan Branch of Shanghai 6th People's Hospital Affiliated to Shanghai Jiaotong University, 147 Jiankang Road, Jinshan District, Shanghai 201599, PR China.

Blood Reviews
|May 2, 2016
PubMed
Summary

Autophagy, a cellular recycling process, plays a dual role in cancer, potentially suppressing tumors initially but aiding survival in established cancers. Its manipulation offers promising therapeutic strategies for hematological malignancies.

Keywords:
AMPKAutophagyBcl-2Hematological malignancyMicroRNAPI3K

More Related Videos

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
11:39

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

32.5K
Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

2.0K

Related Experiment Videos

Last Updated: Mar 21, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

900
Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
11:39

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

32.5K
Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

2.0K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • Autophagy is a fundamental cellular process for degrading and recycling intracellular components, crucial for maintaining homeostasis under stress.
  • Dysfunctional autophagy is implicated in various diseases, including hematological malignancies, highlighting its complex role in cancer initiation and progression.
  • While basal autophagy can be tumor-suppressive, excessive autophagy often promotes cancer cell survival, particularly in established malignancies.

Purpose of the Study:

  • To review recent advancements in understanding the autophagy machinery.
  • To explore the intricate association between autophagy and the therapy of hematological malignancies.
  • To discuss emerging autophagy-based therapeutic strategies for blood cancers.

Main Methods:

  • Literature review of current research on autophagy.
  • Analysis of studies investigating autophagy's role in hematological malignancies.
  • Examination of novel therapeutic approaches targeting autophagy.

Main Results:

  • Autophagy exhibits context-dependent roles, acting as tumor-suppressive or pro-survival depending on the cancer stage and type.
  • Evidence strongly supports autophagy's critical involvement in the development and treatment of hematological cancers.
  • Various autophagy-modulating strategies, including inhibitor combinations and novel manipulations, show therapeutic potential.

Conclusions:

  • Autophagy is a key player in hematological malignancies, offering significant therapeutic opportunities.
  • Targeting autophagy, through inhibitors like chloroquine or novel approaches like Bcl-2 family regulation, presents promising avenues for cancer treatment.
  • Further elucidation of autophagy's principles and clinical applications is essential for optimizing its use in treating blood cancers.