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A Risk of Bias Assessment of Randomized Controlled Trials (RCTs) on Periodontal Regeneration Published in 2013
Satheesh Elangovan1, Sivaraman Prakasam2, Praveen Gajendrareddy3
1BDS, ScD, DMSc, Department of Periodontics, Oregon Health and Science University School of Dentistry, Portland, OR 97239, USA.
The Journal of Evidence-Based Dental Practice
|May 3, 2016
Summary
A review of 2013 periodontal regeneration trials found over 40% had a high risk of bias. This highlights the need for careful appraisal of randomized controlled trials (RCTs) before clinical application.
Area of Science:
- Periodontology
- Biomaterials Science
- Evidence-Based Dentistry
Background:
- Periodontal regeneration research relies heavily on randomized controlled trials (RCTs) to establish treatment efficacy.
- Assessing the quality of evidence, particularly the risk of bias, is crucial for informed clinical decision-making.
Purpose of the Study:
- To evaluate the risk of bias in randomized controlled trials (RCTs) published in 2013 that focused on periodontal regeneration.
Main Methods:
- A systematic search identified 17 relevant RCTs published in 2013.
- Three independent reviewers assessed the risk of bias using the Cochrane risk of bias tool.
- Data on study characteristics, including biomaterials, follow-up duration, and funding, were extracted.
Main Results:
- Over 40% of the included RCTs exhibited a high risk of bias, with less than 30% demonstrating a low risk.
- While domains like sequence generation and outcome reporting were addressed in 70% of trials, only 47% adequately reported allocation concealment.
Conclusions:
- A significant proportion of periodontal regeneration RCTs from 2013 had a high risk of bias.
- Clinicians should critically appraise RCTs before applying findings to practice, and further research should focus on improving methodological rigor.
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