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Testosterone Therapy and Prostate Cancer.

Emily Davidson1, Abraham Morgentaler1

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PubMed
Summary

Androgens have a limited effect on prostate cancer growth, reaching maximum stimulation at low testosterone levels. Testosterone therapy is increasingly offered to men with a history of prostate cancer, with reassuring initial results.

Keywords:
AndrogensHypogonadismProstateProstate cancerProstate-specific antigenTestosteroneTestosterone deficiency

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Area of Science:

  • Endocrinology
  • Urology
  • Oncology

Background:

  • The relationship between androgens and prostate cancer is evolving.
  • Testosterone therapy use is changing due to new insights.

Purpose of the Study:

  • To review the evidence on testosterone and prostate cancer.
  • To assess the safety of testosterone therapy in men with a history of prostate cancer.

Main Methods:

  • Literature review of studies on androgens and prostate cancer.
  • Analysis of data regarding testosterone therapy in patients with prior prostate cancer.

Main Results:

  • Androgen stimulation of prostate cancer growth follows a saturation model.
  • Maximal stimulation occurs at low testosterone concentrations (around 250 ng/dL).
  • Current data on testosterone therapy in men with a history of prostate cancer are reassuring.

Conclusions:

  • The saturation model explains the limited impact of androgens on prostate cancer growth.
  • Testosterone therapy may be a viable option for select men with a history of prostate cancer, pending further research.