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Related Experiment Videos

Erythema multiforme due to griseofulvin.

M H Rustin1, C B Bunker, P M Dowd

  • 1Department of Dermatology, University College and Middlesex School of Medicine, Middlesex Hospital, London, U.K.

The British Journal of Dermatology
|March 1, 1989
PubMed
Summary

Griseofulvin, an antifungal medication, has been linked to a rare side effect: erythema multiforme. This report details three cases, adding to the limited documented evidence of this adverse drug reaction.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Internal Medicine

Background:

  • Griseofulvin is a widely used antifungal agent.
  • Erythema multiforme is an acute, immune-mediated mucocutaneous reaction.

Observation:

  • Three patients developed erythema multiforme while undergoing griseofulvin therapy.
  • The onset of the skin condition occurred during treatment with this antifungal medication.

Findings:

  • This study documents three new cases of erythema multiforme associated with griseofulvin.
  • These cases represent the first documented instances in the English and American literature.

Implications:

  • Clinicians should be aware of the potential for griseofulvin to induce erythema multiforme.

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  • Further investigation into the mechanism of this adverse drug reaction may be warranted.