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Coeliac disease in patients with short stature: A tertiary care centre experience

Prashant Singh1, Piyush Kumar Sharma1, Abhishek Agnihotri1

  • 1Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.

The National Medical Journal of India
|May 3, 2016
PubMed

Insights

Approximately 11% of children with short stature have coeliac disease. Chronic diarrhoea and anaemia are key predictors, with significant growth improvement on a gluten-free diet.

Area of Science:

  • Paediatric Endocrinology
  • Gastroenterology
  • Genetics

Background:

  • Short stature affects a significant number of children, with diverse underlying causes.
  • Coeliac disease, an autoimmune disorder triggered by gluten, can manifest with growth impairment.

Purpose of the Study:

  • To determine the prevalence of coeliac disease in children with short stature.
  • To identify predictors of coeliac disease in this pediatric population.

Main Methods:

  • Retrospective review of 432 children with short stature evaluated between 2008-2011.
  • Screening for coeliac disease using IgA-anti-tissue transglutaminase antibody.
  • Diagnosis confirmed using modified European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) criteria.

Main Results:

  • Coeliac disease was diagnosed in 10.9% of children with short stature.
  • Chronic diarrhoea (OR 15.7) and anaemia (OR 4.9) were significant predictors.
  • Patients showed improved growth velocity (8.1 cm/year) on a gluten-free diet.

Conclusions:

  • Coeliac disease is a notable cause of short stature in children.
  • Screening for coeliac disease is recommended in children with short stature, particularly those with chronic diarrhoea or anaemia.
  • A gluten-free diet effectively improves growth in affected children.
Abstract

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