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Related Experiment Video

Updated: Mar 21, 2026

A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice
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PEG capped methotrexate silver nanoparticles for efficient anticancer activity and biocompatibility.

Zarmina Muhammad1, Abida Raza2, Sana Ghafoor1

  • 1School of Mechanical & Manufacturing Engineering, National University of Sciences & Technology, H-12 Campus, Islamabad, Pakistan.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|May 3, 2016
PubMed
Summary

Polyethylene glycol-coated methotrexate silver nanoparticles (PEG-Ag-MTX) show enhanced anticancer activity and reduced toxicity compared to methotrexate alone. Further in-vivo studies are recommended for potential cancer treatment applications.

Keywords:
Anticancerous drugChemotherapeuticsHemocompatibilityMethotrexatePegylationSilver nanoparticles

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Nanocarriers improve drug delivery by enhancing blood retention, reducing efflux, and enabling targeted delivery.
  • Methotrexate (MTX) is a cancer therapeutic, but high doses cause hepatic and renal toxicity.
  • Developing safer MTX delivery systems is crucial for effective cancer treatment.

Purpose of the Study:

  • To synthesize and characterize polyethylene glycol-coated methotrexate silver nanoparticles (PEG-Ag-MTX).
  • To evaluate the anticancer activity and biocompatibility of PEG-Ag-MTX nanoparticles.
  • To explore PEG-Ag-MTX as a potential nanocarrier for methotrexate-based cancer therapy.

Main Methods:

  • Synthesis of Ag-MTX nanoparticles via chemical reduction.
  • Coating of Ag-MTX nanoparticles with polyethylene glycol (PEG).
  • Characterization using Ultraviolet-Visible Spectroscopy and Fourier Transform Infrared Spectroscopy.

Main Results:

  • PEG-Ag-MTX nanoparticles were successfully synthesized with an average size of 12nm.
  • Enhanced anticancer activity was observed against the MCF-7 cell line.
  • PEG-Ag-MTX nanoparticles demonstrated significantly lower hemolytic activity compared to MTX alone.

Conclusions:

  • PEG-Ag-MTX nanoparticles represent a promising nanocarrier for methotrexate delivery.
  • This approach may lead to cancer treatments with reduced side effects.
  • Further in-vivo investigations are warranted to fully explore their therapeutic potential.