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Updated: Mar 21, 2026

Deriving the Time Course of Glutamate Clearance with a Deconvolution Analysis of Astrocytic Transporter Currents
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AGC1/2, the mitochondrial aspartate-glutamate carriers

N D Amoedo1, G Punzi2, E Obre3

  • 1Univ. Bordeaux, U1211, Bordeaux, France; INSERM, U1211, Bordeaux, France; Instituto de Bioquímica Médica Leopoldo De Meis, UFRJ, Rio de Janeiro, Brazil.

Biochimica Et Biophysica Acta
|May 3, 2016
PubMed
Summary

Aspartate/glutamate carriers (AGCs) transport mitochondrial aspartate to the cytosol. AGCs are crucial for cell metabolism, function, and disease, prompting drug screening for modulators.

Keywords:
AGC1AGC2AralarAspartateCalcium signalingCancer metabolismCitrinEnergy metabolismGlutamateMalate-aspartate shuttleMitochondriaNeuron physiologyRare diseasesTransport assays

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