Related Experiment Video
Updated: Aug 1, 2026
08:32
Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's Membrane
Published on: April 12, 2018
Fundus changes in (type II) mesangiocapillary glomerulonephritis simulating drusen: a histopathological report
J Duvall-Young1, M K MacDonald, N M McKechnie
1Princess Alexandra Eye Pavilion, Royal Infirmary, Edinburgh.
The British Journal of Ophthalmology
|April 1, 1989
Summary
Histopathological examination revealed kidney-like deposits in the eye of a patient with dense deposit disease. This finding offers new insights into the ocular manifestations of this rare glomerulonephritis.
Area of Science:
- Ophthalmology
- Nephrology
- Pathology
Background:
- Type II mesangiocapillary glomerulonephritis, also known as dense deposit disease, is a rare kidney disorder.
- The characteristic renal lesion involves electron-lucent deposits within the glomerular basement membrane.
Observation:
- Histopathological examination of the eye in a patient with dense deposit disease was performed.
- The study focused on identifying any ocular manifestations related to the underlying condition.
Findings:
- For the first time, deposits morphologically similar to those pathognomonic for dense deposit disease in the kidney were found in Bruch's membrane of the eye.
- The clinical fundus appearance mimicked that of drusen, commonly seen in age-related macular degeneration.
Implications:
- This discovery suggests a potential systemic involvement of dense deposit disease beyond the kidneys.
- Understanding these ocular findings may lead to earlier diagnosis and improved management strategies for patients.
- Further research is warranted to elucidate the exact nature and origin of these deposits in Bruch's membrane.
Related Concept Videos
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:28Diabetic Nephropathy
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
01:23Cirrhosis I: Introduction
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...