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Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.

Carsten Merkwirth1, Virginija Jovaisaite2, Jenni Durieux3

  • 1Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; The Glenn Center for Research on Aging, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; The Paul F. Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720, USA.

Cell
|May 3, 2016
PubMed
Summary

Mild mitochondrial stress benefits lifespan by activating the unfolded protein response (UPR(mt)). Epigenetic regulators, histone demethylases, control this longevity pathway, conserved across species from worms to mice.

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