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Frequency of hemorrhagic complications on abdominal CT in patients with warfarin therapy

Sunyoung Lee1, Dongil Choi1, Woo Kyoung Jeong1

  • 1Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Clinical Imaging
|May 3, 2016
PubMed

Insights

Hemorrhagic complications occurred in 11.5% of patients on warfarin therapy undergoing abdominal CT scans. Higher anticoagulation intensity (INR) was linked to increased bleeding risk.

Area of Science:

  • Radiology
  • Internal Medicine
  • Pharmacology

Background:

  • Warfarin is a common anticoagulant.
  • Abdominal CT scans are frequently used in clinical practice.
  • Hemorrhagic complications are a known risk of anticoagulation therapy.

Purpose of the Study:

  • To determine the incidence of hemorrhagic complications on abdominal CT in patients receiving warfarin.
  • To assess the relationship between anticoagulation intensity and bleeding risk.

Main Methods:

  • A retrospective study of 646 patients on warfarin therapy.
  • Inclusion criteria: International Normalized Ratio (INR) > 3.0 and abdominal CT within one month of INR measurement.
  • Analysis of abdominal CT scans for hemorrhagic complications.

Main Results:

  • Hemorrhagic complications were identified in 74 patients (11.5%).
  • A statistically significant correlation was found between the frequency of hemorrhagic complications and anticoagulation intensity (P<.001).

Conclusions:

  • Hemorrhagic complications are not uncommon in patients on warfarin therapy undergoing abdominal CT.
  • Higher INR values are associated with a greater likelihood of bleeding complications.
Abstract

Keywords:
Abdominal CTHemorrhagic complicationsInternational normalized ratio (INR)Warfarin therapy

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