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Magnetic resonance enterography in Crohn's disease: new simple proposal to assess disease activity

Elsa Iannicelli1, Isabella Martini1, Claudia Fantini1

  • 1Radiology Unit, "Sapienza" University of Rome, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189, Rome, Italy.

Clinical Imaging
|May 3, 2016
PubMed
Abstract

Insights

Magnetic resonance enterography (MRE) accurately assesses Crohn's disease (CD) activity. MRE findings correlate with C-reactive protein, supporting its use in evaluating disease severity.

Area of Science:

  • Gastroenterology
  • Radiology
  • Medical Imaging

Background:

  • Crohn's disease (CD) is a chronic inflammatory bowel disease.
  • Accurate assessment of CD activity is crucial for effective management.
  • Current methods for evaluating CD activity have limitations.

Purpose of the Study:

  • To determine the accuracy of magnetic resonance enterography (MRE) in evaluating Crohn's disease (CD) activity.
  • To establish the correlation between MRE findings and established clinical and laboratory markers of inflammation.

Main Methods:

  • Seventy-seven patients with CD underwent MRE.
  • MRE findings were analyzed for associations with the Harvey-Bradshaw Index and C-reactive protein (CRP).
  • A novel MRE scoring system was developed and correlated with clinical and laboratory data.

Main Results:

  • The developed MRE score demonstrated a significant correlation with CRP levels (P=.003).
  • Increased contrast enhancement on MRE showed significant association with CRP (P=.002).
  • The 'comb sign' on MRE was also significantly associated with CRP levels (P=.001).

Conclusions:

  • MRE is a valuable tool for assessing Crohn's disease activity.
  • MRE findings, including a new scoring system, correlate well with inflammatory markers like CRP.
  • These results support the integration of MRE into the routine evaluation of CD.
Keywords:
Crohn’s diseaseInflammatory bowel diseaseMagnetic resonance enterography scoreMagnetic resonance imaging

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