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Related Experiment Videos

Microorganisms in recurrent aphthous ulcerations.

O Donatsky, T Justesen, K Lind

    Scandinavian Journal of Dental Research
    |September 1, 1977
    PubMed
    Summary
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    This study investigated oral bacteria in recurrent aphthous ulcerations (RAU), finding alpha-hemolytic streptococci and other bacteria. No viruses or yeasts were significantly linked to RAU, suggesting a bacterial role in oral ulcer pathogenesis.

    Area of Science:

    • Oral microbiology
    • Immunology

    Background:

    • Recurrent aphthous ulcerations (RAU) are common oral lesions.
    • The microbial etiology of RAU remains incompletely understood.

    Purpose of the Study:

    • To characterize the cultivable bacterial flora in RAU.
    • To investigate the potential role of yeasts, mycoplasmas, and viruses in RAU pathogenesis.

    Main Methods:

    • Biopsies from RAU, experimental oral ulcerations (EOU), and normal oral mucosa (NOM) were cultured aerobically and anaerobically.
    • RAU biopsies were tested for yeasts, mycoplasmas, viruses, and herpes virus antigen.

    Main Results:

    • Predominant bacteria in RAU included alpha-hemolytic streptococci, coagulase-negative staphylococci, and Neisseria.

    Related Experiment Videos

  • EOU showed alpha-hemolytic streptococci, Corynebacterium, Veillonella, Neisseria, and Haemophilus.
  • NOM cultures were dominated by alpha-hemolytic streptococci; yeasts were rare, and no mycoplasmas, viruses, or herpes virus antigen were detected.

    • Conclusions:

    • Specific bacterial profiles are associated with RAU.
    • Current evidence does not strongly support a viral or yeast etiology for RAU.