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Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms

Karen Yap1, Yixin Xiao2, Brad A Friedman3

  • 1MRC Centre for Developmental Neurobiology, King's College London, London SE1 1UL, UK.

Cell Reports
|May 3, 2016
PubMed
Summary

Alternative splicing creates protein diversity. In neurons, co-expressed splice variants of the Cdc42 gene are crucial for proper axon and dendrite development, not a complete isoform switch.

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