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Updated: Mar 21, 2026

Retinal Pathophysiological Evaluation in a Rat Model
Published on: May 6, 2022
Retinoids have therapeutic action in type 2 diabetes
Dilnasheen Meerza1, Sarah Iqbal1, Sufian Zaheer2
1Department of Biochemistry, Aligarh Muslim University, Aligarh, India.
Objective:
Uncontrolled diabetes is associated with a compromised antioxidant state of the body. Consequentially, the reactive oxygen species generated lead to oxidative insult and associated complications. Based on this paradigm, exogenous antioxidant supplementation is thought to exert a therapeutic role in type 2 diabetes (T2-D) biology.
Methods:
In the present study, the effect of vitamin A supplementation was assessed on disease progression in T2-D BALB/c mice. Animals were divided into three groups. With the exception of control, the mice in remaining groups were induced with experimental T2-D. After a 15-day treatment protocol, the mice were sacrificed and various parameters were analyzed.
Results:
The treated group evidenced a considerable improvement in total antioxidant potential and glycemic control. A therapeutic effect on beta cell degeneration as compared to the diabetic group was also found.
Conclusions:
The study illustrates the antihyperglycemic and antioxidant potential of vitamin A in vivo, which has potential to serve as a dietary intervention in T2-D.
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