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Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

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Langerhan's Cell Sarcoma: Two Case Reports.

Tasneem A Kaleem¹, Michael H Schild¹, Daniel Miller¹

¹Department of Radiation Oncology, Mayo Clinic Florida , Jacksonville, FL, USA.

|May 3, 2016

Summary

This summary is machine-generated.

Langerhan's cell sarcoma (LCS) is a rare cancer. This study presents two distinct LCS cases, highlighting varied presentations and treatment responses for this aggressive neoplasm.

Keywords:

Langerhan’s Medicine cancer oncology rare sarcoma tumor

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Area of Science:

Oncology
Pathology

Background:

Langerhan's cell sarcoma (LCS) is an exceptionally rare neoplasm.
Published cases of LCS are limited, with only sixty-six documented instances.

Observation:

Two distinct LCS patient cases are presented, showcasing divergent clinical presentations.
Case 1: A patient with a history of high-grade myxofibrosarcomas presented with a solitary LCS skin lesion, treated with resection and radiotherapy, experiencing locoregional recurrence.
Case 2: A patient presented with bone marrow and splenic involvement, leukocytosis, and thrombocytopenia.

Findings:

Case 1 patient remains alive two years post-diagnosis after repeated resection for locoregional recurrence.
Case 2 patient achieved a complete remission with combination chemotherapy (etoposide, prednisone, oncovorin, cyclophosphamide, adriamycin), normalization of blood counts, and successful splenectomy.

Implications:

The varied presentations underscore the diagnostic challenges of LCS.
Successful treatment strategies may involve multimodal approaches tailored to individual patient disease burden and characteristics.
Further research into LCS pathogenesis and treatment is warranted given its rarity and poor prognosis.