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Related Experiment Video

Updated: Mar 21, 2026

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes
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Strain-Dependent Gene Expression during Mouse Embryonic Palate Development.

Jiu-Zhen Jin1, Jixiang Ding2

  • 1Department of Molecular, Cellular and Craniofacial Biology and Birth Defects Center, University of Louisville School of Dentistry, Louisville, KY 40202, USA; Division of Cardiovascular Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.

Journal of Developmental Biology
|May 3, 2016
PubMed
Summary

Mouse palate development shows strain-dependent gene expression for Meox-2 and Fgfr1. Different mouse strains exhibit unique patterns for these key developmental genes.

Keywords:
Black Swiss and C57B6Fgfr1Meox-2Swiss Webstersecondary palate

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Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Strain background is known to influence gene function in growth and development.
  • Limited information exists on how strain background impacts gene expression patterns.

Purpose of the Study:

  • To investigate the effect of different mouse strain backgrounds on gene expression patterns during palate development.
  • To analyze the expression of homeobox gene Meox-2 and FGF receptor 1 gene Fgfr1.

Main Methods:

  • Comparative analysis of gene expression patterns.
  • Utilized three distinct mouse strains: C57B6 (inbred), Swiss Webster (outbred), and Black Swiss (outbred).
  • Examined expression on specific embryonic days (E11.5, E12.5, E14.5) during mouse palate development.

Main Results:

  • Meox-2 expression patterns varied significantly across the three strains, with differences in spatial distribution and intensity over time.
  • Fgfr1 expression at E11.5 was strain-dependent, ranging from undetectable in C57B6 to exclusively posterior in Swiss Webster and anterior in Black Swiss.
  • Demonstrated distinct spatiotemporal expression profiles for Meox-2 and Fgfr1 influenced by the genetic background.

Conclusions:

  • The strain background critically affects gene expression patterns during mouse palate development.
  • These findings highlight the importance of considering genetic background in studies of gene function and developmental processes.
  • Meox-2 and Fgfr1 serve as examples of genes exhibiting strain-dependent expression during embryonic development.