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Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope
Published on: August 2, 2024
In vivo imaging of dendritic pruning in dentate granule cells
J Tiago Gonçalves1, Cooper W Bloyd1, Matthew Shtrahman1
1Laboratory of Genetics, Salk Institute for Biological Sciences, La Jolla, California, USA.
Abstract:
We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.
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