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Updated: Mar 21, 2026
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Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
Published on: March 18, 2022
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Diseases of Subchondral Bone 1
Frantz Lerebours1, Neal S ElAttrache, Bert Mandelbaum
1*Cedars-Sinai Medical Center †Kerlan Jobe Orthopedics at Cedars-Sinai, Los Angeles ‡Santa Monica Orthopaedic and Sports Medicine Group, Santa Monica, CA.
Sports Medicine and Arthroscopy Review
|May 3, 2016
Summary
The subchondral bone and articular cartilage interface is crucial for cartilage health. Understanding its structure and function is key to understanding cartilage disease pathogenesis.
Area of Science:
- Orthopedics
- Cartilage Biology
- Subchondral Bone Research
Background:
- The subchondral zone is vital for maintaining articular cartilage structure and biochemistry.
- The subchondral bone/articular surface interface is a critical area for cartilage health.
Purpose of the Study:
- To review the structure, function, and pathophysiology of the normal subchondral bone/articular surface interface.
- To provide foundational knowledge for understanding cartilage disease pathogenesis.
Main Methods:
- Literature review of existing research on the subchondral bone/articular surface interface.
- Synthesis of information regarding the structural and biochemical roles of the subchondral zone.
Main Results:
- The subchondral zone's role in structural maintenance of articular cartilage.
- The subchondral zone's role in biochemical maintenance of articular cartilage.
Conclusions:
- Comprehensive understanding of the subchondral bone/articular surface interface is essential.
- This knowledge is fundamental for comprehending the pathogenesis of various cartilage diseases.
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