Psoriasis registries worldwide: systematic overview on registry publications

Area of Science:

• Dermatology
• Clinical Research Methodology
• Real-World Evidence

Background:

• Clinical trials have limitations in assessing long-term treatment effects and onset latency for new therapies.
• Patient registries collect prospective, real-world data from diverse patient populations in routine clinical practice.

Purpose of the Study:

• To identify existing psoriasis patient registries through published literature.
• To evaluate the treatment classes, patient populations, research questions, and measurement instruments used in these registries.

Main Methods:

• Systematic review of Medline (PubMed) and Embase (Ovid) databases.
• Publications on psoriasis patient registries were identified and cross-validated.
• Data collection occurred in October 2015.

Main Results:

• Fourteen patient registries for long-term psoriasis observation were identified, primarily located in Europe and established since 2005.
• Registries cover patients on conventional systemics and biologics, with patient numbers ranging from 35 to over 12,000.
• Publications focused mainly on safety, treatment outcomes, baseline characteristics, drug survival, predictor analyses, and treatment patterns.

Conclusions:

• Numerous patient registries gather longitudinal data on systemic psoriasis treatment, reflecting objectives of safety and effectiveness.
• Combining data across registries presents methodological challenges.
• Harmonization of data collection is essential for achieving comparability and combinability of data across psoriasis registries.