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Microparticles in sickle cell anaemia: promise and pitfalls

Robert P Hebbel1, Nigel S Key2

  • 1Division of Haematology-Oncology-Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.

British Journal of Haematology
|May 3, 2016
PubMed

Insights

Sickle cell disease patients have blood microparticles (MPs) from various cells. These MPs are linked to disease, serve as biomarkers, and influence coagulation and sickle cell disease pathobiology.

Area of Science:

  • Hematology
  • Cell Biology
  • Biomarker Discovery

Background:

  • Sickle cell disease (SCD) is characterized by abnormal red blood cells.
  • Blood from SCD patients contains microparticles (MPs) from diverse cellular origins.

Purpose of the Study:

  • To discuss the nature and relevance of MPs in SCD.
  • To explore MP profiling, detection challenges, and roles in SCD pathobiology.

Main Methods:

  • Literature review and discussion of existing research on MPs in SCD.
  • Analysis of MP origins, functions, and implications in SCD.

Main Results:

  • MPs are derived from red cells, platelets, monocytes, and endothelial cells in SCD.
  • MPs play roles in supporting coagulation and influencing SCD pathobiology.

Conclusions:

  • Microparticles are significant in SCD, acting as potential biomarkers.
  • Understanding MPs is crucial for comprehending SCD's complex mechanisms and potential therapeutic targets.
Keywords:
biomarkerextracellular vesicleflow cytometrymicroparticlesickle cell anaemia

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