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How we treat bleeding associated with direct oral anticoagulants
Giuseppe Marano1, Stefania Vaglio1, Simonetta Pupella1
1Italian National Blood Centre, National Institute of Health, Rome, Italy.
Abstract:
Direct oral anticoagulants are at least as effective as vitamin K antagonists for the prevention and treatment of thromboembolism. Unfortunately, differently from vitamin K antagonists, they have the great drawback of lacking specific antidotes in the case of bleeding or emergency situations such as trauma, stroke requiring thrombolysis, and urgent surgery. The progressive development of antidotes for these new drugs, which, it is hoped, will become available in the near future, will allow better and safer management of the rapid reversal of their anticoagulant effect.
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