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Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
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Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
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Myasthenia Gravis: Diagnostic Tests01:15

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
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Related Experiment Video

Updated: Mar 21, 2026

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
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Resveratrol and Myopathy.

Jean Bastin1, Fatima Djouadi2

  • 1INSERM UMRS 1124, Université Paris Descartes, Paris 75006, France. jean.bastin@inserm.fr.

Nutrients
|May 3, 2016
PubMed
Summary
This summary is machine-generated.

Resveratrol shows promise for treating mitochondrial myopathies and Duchenne Muscular Dystrophy by improving skeletal muscle energy metabolism. Further research is needed to fully understand its therapeutic potential.

Keywords:
Duchenne muscular dystrophymetabolic myopathiesmitochondrial disordersresveratrol

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Area of Science:

  • Mitochondrial Medicine
  • Skeletal Muscle Physiology
  • Nutraceuticals and Therapeutics

Background:

  • Resveratrol, a natural polyphenol, exhibits antioxidant and anti-inflammatory properties.
  • Emerging evidence suggests resveratrol impacts mitochondrial metabolic pathways, including fatty acid oxidation and oxidative phosphorylation.
  • Skeletal muscle's role in resveratrol's beneficial effects is under-explored despite its potential.

Purpose of the Study:

  • To review resveratrol's potential to correct mitochondrial metabolic deficiencies in myopathies.
  • To explore resveratrol's therapeutic effects in Duchenne Muscular Dystrophy (DMD).
  • To highlight the role of skeletal muscle in resveratrol's pleiotropic effects.

Main Methods:

  • Literature review of existing studies on resveratrol, mitochondrial myopathies, and Duchenne Muscular Dystrophy.
  • Analysis of research on resveratrol's impact on cellular energy metabolism and signaling pathways (PGC-1α, SIRT1, AMP-kinase).
  • Examination of data linking mitochondrial dysfunction to disease pathogenesis in skeletal muscle disorders.

Main Results:

  • Resveratrol may ameliorate or correct inherited fatty acid β-oxidation defects and respiratory chain deficiencies causing myopathies.
  • Recent data suggest therapeutic benefits of resveratrol in Duchenne Muscular Dystrophy, potentially by addressing associated mitochondrial dysfunctions.
  • Resveratrol's effects on skeletal muscle mitochondrial metabolism are key to its potential therapeutic applications.

Conclusions:

  • Resveratrol holds significant therapeutic potential for inherited myopathies and Duchenne Muscular Dystrophy.
  • Targeting skeletal muscle mitochondrial metabolism with resveratrol could offer novel treatment strategies.
  • Further delineation of resveratrol's signaling pathways in muscle is warranted.