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Reactive astrocytes in lesioned rat spinal cord: effect of neural transplants
1Department of Pathology, University of Alberta, Edmonton, Canada.
Brain Research Bulletin
|January 1, 1989
Abstract:
The astroglial reaction following a laceration-type surgical lesion of rat spinal cord is recognized by hypertrophy of astrocytes. This phenomenon can be readily demonstrated by enhanced immunoreactivity for glial fibrillary acidic protein (GFAP) and a recently discovered 30 kD protein (J1-31 antigen). The results reported in this article lead to the conclusion that the astroglial reaction is not influenced significantly by the transplantation of embryonic neocortical tissue to the cavity of a laceration-type lesion. These observations could be relevant to the assessment of strategies for treatment of spinal cord injury.