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Positive feedback during sulfide oxidation fine-tunes cellular affinity for oxygen.

Abbas Abou-Hamdan1, Céline Ransy1, Thomas Roger2

  • 1Inserm U1016, Institut Cochin, 75014 Paris, France; CNRS UM8104, Institut Cochin, 75014 Paris, France; Université Paris Descartes UMR-S1016, Institut Cochin, 75014 Paris, France.

Biochimica Et Biophysica Acta
|May 4, 2016
PubMed
Summary

Sulfide (H2S) influences cellular oxygen affinity by balancing its roles as an electron donor and cytochrome oxidase inhibitor. Its oxidation rate, not just concentration, dictates oxygen dependence in cells.

Keywords:
Hydrogen sulfideHypoxiaMitochondriaPositive feedbackSulfide quinone reductase

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