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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Production of Formed Elements01:34

Production of Formed Elements

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Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
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Related Experiment Video

Updated: Mar 21, 2026

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
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Regulation of Blood Stem Cell Development.

E Dzierzak1, E de Pater2

  • 1Erasmus MC, Rotterdam, The Netherlands; MRC Centre for Inflammation Research and MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.

Current Topics in Developmental Biology
|May 4, 2016
PubMed
Summary
This summary is machine-generated.

Hematopoietic stem cells (HSCs) are crucial for blood formation. Research focuses on understanding how endothelial cells naturally transform into HSCs during embryonic development for transplantation therapies.

Keywords:
Aorta-gonad-mesonephrosEmbryoHematopoietic stem cellsHemogenic endothelial cellsHemogenic programTransdifferentiation

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Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Area of Science:

  • Developmental biology
  • Hematopoiesis
  • Stem cell biology

Background:

  • Blood system formation is a fundamental research challenge.
  • Hematopoietic stem cells (HSCs) are vital for adult blood production and transplantation.
  • Understanding HSC generation during embryonic development is critical.

Purpose of the Study:

  • To review advances in hematopoietic development.
  • To focus on the transdifferentiation of endothelial cells to HSCs.
  • To identify cells and molecules regulating HSC initiation.

Main Methods:

  • Review of existing literature on hematopoietic development.
  • Analysis of the association between vascular and hematopoietic systems.
  • Examination of hematopoietic cell mobility and embryonic roles.

Main Results:

  • Hematopoietic and vascular systems develop closely.
  • Embryonic hematopoietic system is essential for adult blood development.
  • Endothelial cell transdifferentiation to HSCs is a key process.

Conclusions:

  • Significant progress has been made in understanding hematopoietic development.
  • Endothelial-to-HSC transdifferentiation is a key regulatory mechanism.
  • Further research is needed to harness this process for clinical applications.